A phenome-wide investigation of risk factors for severe COVID-19Article Published on 2023-01-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] COVID-19 GWAS mendelian randomization obesity. UK biobank [DOI] 10.1002/jmv.28264 PMC 바로가기
Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Genome-wide association studies of COVID-19: Connecting the dotsReview Published on 2022-12-012023-07-10 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), [키워드] COVID-19 genetic variants GWAS Host SARS-CoV-2. [DOI] 10.1016/j.meegid.2022.105379 PMC 바로가기 [Article Type] Review
An explainable model of host genetic interactions linked to COVID-19 severityArticle Published on 2022-10-262022-11-16 Journal: Communications Biology [Category] 변종, 유전자 메커니즘, [키워드] age and gender Analysis classifiers Cohort contributing to covariates COVID-19 COVID-19 severity dataset Factor Features Follow-up Genetic GWAS high accuracy highest Host identify immune pathways immune system increased risk Inflammatory Interaction Italian patients MCC molecular mechanism offer outcome Patient phenotypic predict predicted Predictive screened several variant Severe COVID-19 Infection severity Signaling significantly Stratification stratified Support tested therapeutic intervention Thoracic variant viral infection WES with COVID-19 [DOI] 10.1038/s42003-022-04073-6 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon type I interferon. upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Genome-wide association analyses of common infections in a large practice-based biobankArticle Published on 2022-09-272023-06-02 Journal: BMC Genomics [Category] B형 간염, 두창, 홍역, [키워드] EHR GWAS infection. [DOI] 10.1186/s12864-022-08888-9 PMC 바로가기
Cross-GWAS coherence test at the gene and pathway levelArticle Published on 2022-09-262022-11-16 Journal: PLoS Computational Biology [Category] 변종, [키워드] 25OHD affecting Algorithm analyses analysis approach association bone structure calculated Cell Chemokine receptor coefficients concentrations correlated cumulative datapoint detect distribution Effect effect size expression genetic link Genetic variant Genome-wide association study GWAS immune response independent integrin linear combination medication pathway Pathways positive Precision rheumatoid arthritis serum calcium severity of COVID-19 structures traits utility [DOI] 10.1371/journal.pcbi.1010517 PMC 바로가기
Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] AD-high-risk scores Alzheimer’s disease Astrocyte Cell cell population cognitive Cognitive impairment COVID-19 COVID-19 patients demonstrated disease disease-associated dysfunction GWAS identify mechanism Neuroinflammation Neuron neuronal pathway proteomic reported reveal RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection single-nucleus RNA sequencing. subtype synaptic syndrome target therapeutic intervention transcriptomic [DOI] 10.3389/fimmu.2022.967356 PMC 바로가기
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] association B.1 lineage candidate gene case-control study CCL2 cohort of patient contribute COVID-19 COVID-19 case COVID-19 severity Cytokine storm examined genetic loci genetic marker Genetic variant Genome Genome-wide association study genotyped Germany GWAS healthy control Hospitalization Hospitalized Host Host genetic factor host genetics investigated Lineage LZTFL1 MOST objective Pathogenesis patients with COVID-19 phenotype Phylogeny polygenic risk score predict reached reconstructed Result risk risk score SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 strain sequenced severity severity of COVID-19 significantly single nucleotide polymorphisms susceptibility the SARS-CoV-2 genome variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.030 [Article Type] Research article
Genome-wide association study of SARS-CoV-2 infection in Chinese population중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, [키워드] analyzed ANKRD27 association Asymptomatic carried CD200R1L Chinese close contact conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 severity ERAP1 Exome Genetic genetic association genetic variability Genetic variant genetic variants Genome sequencing Genome-wide association study global public health GWAS heterogeneous individual LINC00700 loci locus MAN1A2 molecular NEIL3 pathogenesis of COVID-19 Patient PCNX2 PLCL2 POLR2A Polymorphisms positive provided recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sequencing severity single-nucleotide Single-nucleotide polymorphisms suggested susceptibility Susceptibility. symptomatic patient tested therapeutic options ZMAT3 [DOI] 10.1007/s10096-022-04478-5 PMC 바로가기 [Article Type] Article